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Pathophysiological hyperinsulinemia induces a cholesterolgenic response. Cells were treated with or without 250pM, 500pM, or 5nM insulin (Ins) for 12 hours. Values are mean ± SEM from 3 to 8 experiments. A, Plasma membrane (PM) cholesterol content. B, Hmgcr mRNA expression. C, HMGR protein content. D, SREBP1 protein content. *P < .05 vs untreated control; #P < .05 vs 250pM insulin. A.U. indicates arbitrary units.
