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Hyperinsulinemia promotes and DON protects against transcriptional activation of the Hmgcr promoter. A, Hmgcr pGL2B and phrl-minTK construct was transfected into 3T3-L1 adipocytes. B, After transfection, cells were left untreated or treated with 500pM insulin (Ins) in the presence or absence of DON, and luciferase activity was measured relative to Renilla. Values are mean ± SEM from 3 to 5 experiments. C, The Sp1-binding sites in the Hmgcr promoter region. *P < .05 vs control.
