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FSH reliance on IGF-IR activation is species and cell-type independent. Human or mouse GCs and Sertoli cells were cultured in presence of FSH (50 ng/ml) with or without AEW (0.5μM) for 48 hours before the quantification of Cyp19, P450scc, StAR, and LHR mRNA levels (n = 4). Controls (C) received vehicle. Columns with different letters differ significantly (P < .05).
