Figure 2.

Endogenous DA regulates STDP in CA1 of hippocampal slices via D1R signaling. (A) Bath application of the specific D1R antagonist SCH23390 (10 μM) or DA depletion by preparation in SUC media inhibit t-LTP. For experimental conditions see Figure 1. Green symbols indicate average results for neurons of the ACSF group (ACSF), red symbols indicate results for DA depleted slices (DA depletion), and light blue symbols show results for neurons in ACSF prepared slices, treated with SCH23390 (+10 μM SCH). Inset above shows original traces before and after STDP induction for the three different conditions (small asterisk: action potential truncated). (B) AP rise time is significantly longer upon application of SCH23390 compared to ACSF (^*p<0.05).