. Author manuscript; available in PMC: 2013 Mar 6.

Published in final edited form as: J Alzheimers Dis. 2012;30(1):109–120. doi: 10.3233/JAD-2012-111850

Table 3.

Brain areas showing changes between baseline and 2-year follow-up in EC, MCI and AD groups.

Group	Region	Cluster size (num. voxels)	Coordinates (X Y Z)	Z scores of maximum	p (FDR) cluster	p (FDR) voxel
EC	No significant changes
MCI	Bilateral Middle and Posterior Cingulate, Left Frontal Lobe (Supplementary Motor Area)	1188	8 −22 34	4.59	<0.001	0.028
	Left Frontal Lobe (precentral and rolandic), Left Temporal Pole, Left Parietal Lobe (Postcentral gyrus)	722	−56 −4 12	4.30	0.003	0.028
	Left Parietal Lobe and Angular Gyrus.	444	−38 −50 46	4.24	0.023	0.028
AD	Bilateral Middle and Posterior Cingulate, Bilateral Temporal Lobe, Bilateral Supramarginalis, Bilateral Insula, Bilateral Parietal Lobe (Cuneus, Precuneus and Postcentral gyrus), Bilateral Frontal Lobe (Precentral gyrus, Motor area), Left Occipital Lobe.	78328	2 −40 40	5.54	<0.001	<0.001

EC: Elderly Controls; MCI: Mild Cognitive Impairment; AD: Alzheimer’s disease.