Figure 7.

Dependence of the critical APC concentration for target gene induction on the inhibition constant. (A) The steady state concentration of target gene mRNA is compared assuming different values of the inhibition constant K_i: 23, 100, and 500 nM (black, dark gray, and light gray, respectively). For each curve, the steady state is normalized to the respective maximal mRNA concentration. (B) The absolute values of the concentration changes along the curves of (A) are plotted. The maximal calculated change is color-coded in black.