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Input (β-catenin/TCF) and output (mRNA) time courses of the iFFL motif. (A) A stepwise increase of the β-catenin/TCF concentration leads to (B) a perfect adaptation of the target gene mRNA. The dynamics of the mRNA is independent of the initial absolute concentration of β-catenin/TCF if the same fold change in the β-catenin/TCF level is induced.
