Fig. 1.
Decreased rate of tumor growth observed in mice lacking the A2A adenosine receptor. C57Bl/6 WT and A2A KO mice were injected s.c. with 106 luciferase expressing EL4 cells. Growth of the tumor was monitored by anesthetization, followed by i.p. injection with 1.5 mg of luciferin-K + salt and imaging with a IVIS system. a A2A KO mice showed significantly reduced rate of tumor growth compared to WT controls. b Detailed view of day 26 post-inoculation. c Time course of EL4-luciferase tumor growth. *P < 0.05