Table 4.

Summary of postoperative treatment strategies for localized tumors (SIOP)

	Stage I	Stage II	Stage III
Low-risk	No further treatment	AV-2a	AV-2
Intermediate-risk	AV-1b	Randomize to AVDc	Randomize to RT or AVD
		or	or
		AV-2	RT or AV-2
High-risk	AVD	HRd + RT	HR + RT

Abbreviations: HR, high-risk; RT, radiation therapy.

^aVincristine weekly for 8 weeks, then on days 1 and 7 with a 2-week interval between courses for 6 courses, actinomycin D every 3 weeks for 9 doses.

^bVincristine weekly for 4 weeks, actinomycin D at day 7.

^cVincristine, actinomycin as per AV-2, doxorubicin every 6 weeks for 4 doses.

^dCyclophosphamide-doxorubicin alternating with etoposide-carboplatin for 34 weeks.