FIG. 4.

Ultrastructural pathology of injured cortex at early injury phase (less than 1 day post-injury; Case #1). (A) Near zone. Neuropil with frequent swollen processes showing high amplitude swollen mitochondria (arrows). Inner membrane-associated dense granular inclusions are present in a mitochondrion (black arrow). (B) Far zone. Slight to moderate cytoplasmic swellings are noticeable. Mitochondria are primarily normal (black arrow) and normal reactive (white-head arrow). (C) Penumbra zone. Slight to moderate cytoplasmic swelling. Mitochondria are predominantly normal orthodox (black arrow) or normal reactive (white head arrow). (D) Far zone. Neuropil with swollen processes showing mitochondrial changes. Note the teardrop-shaped mitochondrial profiles with thin thread-like extension (arrows) suggestive of a thread-grain transition. Scale bars equal 500 nm.