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The Runx2 P1 promoter associates with acetylated histones H3 and H4 in osteoblasts. The graph presents data from chromatin immunoprecipitation analysis with antibodies recognizing acetylated histones H3 and H4. Genomic primers amplify the P1 promoter and the first intron of the Runx2 locus in MC3T3 osteoblasts. The antibodies recognize multiple acetylated forms of histones H3 and H4 (i.e., antibodies are not lysine specific) that generally mark “open” chromatin.
