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. Author manuscript; available in PMC: 2013 Mar 6.
Published in final edited form as: Science. 2012 Jul 12;337(6098):1094–1097. doi: 10.1126/science.1223710

Fig. 1.

Fig. 1

Carbazole derivatives lengthen the circadian period. (A) The chemical structure of carbazole derivatives. (B and C) Luminescence rhythms of Bmal1-dLuc and Per2-dLuc reporter U2OS cells were monitored in the presence of various concentrations of compound. Representative traces (n = 2) are shown in (B). The changes of period and luminescence intensity (an average of 24–120 h; IC50 values are indicated in insets of bottom panels) relative to DMSO control are shown in (C) as mean ± SEM (n = 4). When arrhythmic, the period was not plotted. (D and E) Luminescence rhythms of mPer2Luc knock-in reporter in mouse SCN (D) and lung (E) explants were monitored in the presence of increasing concentration of KL001 (each for 120 h). Data are mean ± SEM (n = 6 for SCN and 5 for lung).