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. Author manuscript; available in PMC: 2013 Apr 15.
Published in final edited form as: Bioorg Med Chem Lett. 2012 Mar 2;22(8):2823–2826. doi: 10.1016/j.bmcl.2012.02.080

Figure 2.

Figure 2

Reverse-phase C18-HPLC traces for the GSH-induced cyclization folding of purified precursors RTD-C3 (A) and RTD-C7 (B). The HPLC traces of the corresponding linear peptide thioester precursor TFA crudes are shown on the left. The thioester linear peptide is marked in each case with an arrow. Other minor peptide products are marked with an asterisk. These compounds were identified as partially oxidized linear peptides by ES-MS and disappear once the cyclization/folding is complete (right HPLC traces).