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. Author manuscript; available in PMC: 2013 Apr 15.
Published in final edited form as: Bioorg Med Chem Lett. 2012 Mar 2;22(8):2823–2826. doi: 10.1016/j.bmcl.2012.02.080

Figure 3.

Figure 3

Characterization of synthetic RTD-1. (A) Inhibition assay of RTD-1 against anthrax lethal factor (LF). LF activity was measured in the presence of increasing concentrations of peptide RTD-1 and it was determined as the rate LF cleaves a FRET-based substrate.32 (B) Summary of the1 H NMR assignments for the backbone protons: Δδ(1H) are the deviations in the chemical shifts of the main chain protons between the values obtained in this work for synthetic RTD-1 and those reported for RTD-1 at pH 6 (Table S1) and pH 4.5.20