Table 2.

Characteristics of current subjects as well as those previously reported to have alterations in BDNF.

Subject	Age/sex	Genotype	Nociception	Psychopathology	Overweight/obese	Mental Dx
1	10/M	Deletion: 22,858,513–29,066,320	Pain insensitivity	ADHD, anxiety disorder, aggressive behaviors	BMI=22.6	PDD-NOS
2	21/F	Deletion: 27, 050, 622–29, 550, 113	self—injurious behaviors	Major depression, generalized anxiety disorder	BMI=51.7	Mild MR
3	2.75/M	Deletion: 23,484,198–27,857,928	N/A	Impaired behavior	mother BMI= 39.5 proband BMI=27.4	GDD in proband; ID in mother
4	16/M	Deletion: 23,002,186–27,956,720	N/A	Adjustment disorder, Major depression, generalized anxiety disorder	BMI= 50.5	PDD
5	7/M	Deletion: 25,649,116–31,566,599	Pain insensitivity	Anxiety, ADHD, temper tantrums, intolerance to frustration	BMI=28.3	Moderate MR
6	3/F	Duplication: 27,179,904–28,837,666	N/A	Not reported	No	Moderate MR and dystonia
42Ref	13/M	Deletion	N/A	Not reported	Yes	MR
12Ref	25/F	Deletion	N/A	Mood disturbances, obsessive–compulsive behavior, temper tantrums, intolerance to frustration requiring antipsychotic medications	Yes	Mild/moderate MR
12Ref	14/F	Deletion	N/A	Chronic anxiety, poor acceptance of change, logorrhea, echolaly, poor social interactions, labile mood, and bouts of aggressiveness and motor agitation that required treatment with risperidone	Yes	PDD: Moderate/severe MR
13Ref	9/F	Position effect due to an inversion	Pain insensitivity	Complex neurobehavioral phenotype, repetitive behaviors, extreme hyperactivity, no concept of danger	Yes	Low IQ

Abbreviations: ADHD: Attention Deficit Hyperactivity Disorder; PDD-NOS: Pervasive Developmental Delay, not objectively specified; MR: Mental retardation; GDD: Global Developmental Delay; ID: intellectual disability IQ: Intelligence quotient. All genomic coordinates according to human reference hg18.