Table 1.
Characteristics and Serological Outcomes of Serofast Patients With Early Syphilis Retreated With Benzathine Penicillin
| Characteristic | Outcome at 12 Months After Initial Treatment (ie, 6 Months After Retreatment) |
|
|---|---|---|
| Seroreversion/Cure (n = 22) | Serofast (n = 60) | |
| Gender (n, % male) | 13, 59% | 32, 53% |
| Age (25th, 50th, and 75th percentiles) | 23, 25, 36 | 23, 30, 36 |
| RPR titers (25th, 50th, and 75th percentiles) | ||
| Baseline | 1:16, 1:32, 1:128 | 1:4, 1:8, 1:32* |
| 6 months | 1:16, 1:32, 1:64 | 1:4, 1:8, 1:16** |
| RPR titers (geometric mean titer [95% CI]) | ||
| Baseline | 34 (19, 62) | 10 (8, 14)*** |
| 6 months | 26 (13, 52) | 8 (6, 11)**** |
| Syphilis stage (n, %) | ||
| Primary | 5, 23% | 9, 15% |
| Secondary | 6, 27% | 19, 32% |
| Early latent | 11, 50% | 32, 53% |
| Initial treatment (n, %) | ||
| Penicillin | 12, 55% | 29, 48% |
| Azithromycin | 10, 46% | 31, 52% |
Abbreviations: CI, confidence interval; RPR, rapid plasma regain.
Wilcoxon 2-sample test: *P = .0004; **P = .001. T test: ***P = .0002; ****P = .0005.