Table 4.
Adjusted Relative Risks and 95% Confidence Intervals for Type I and Type II Endometrial Carcinoma in Relation to Personal and Family Medical History in the NIH-AARP Diet and Health Study, 1995–2006
Self-reported (yes) | No. of Noncases | Subtypes |
|||||
---|---|---|---|---|---|---|---|
Type I (n = 1,312) |
Type II (n = 138) |
||||||
No. | RRa | 95% CI | No. | RRa | 95% CI | ||
Diabetes | 7,491 | 137 | 1.24 | 1.03, 1.49 | 18 | 1.67 | 1.00, 2.79 |
Pheterogeneityb = 0.25 | |||||||
First-degree family history of breast cancer | 13,590 | 130 | 0.80 | 0.67, 0.96 | 28 | 1.93 | 1.27, 2.93 |
Pheterogeneityb = 0.002 | |||||||
First-degree family history of other cancer | 39,072 | 466 | 1.01 | 0.90, 1.14 | 53 | 1.24 | 0.87, 1.75 |
Pheterogeneityb = 0.52 |
Abbreviations: CI, confidence interval; NIH, National Institutes of Health; RR, relative risk.
a Adjusted for age (continuous), oral contraceptive use (ever/never), menopausal hormone therapy use (ever/never), parity (nulliparous, 1, 2, ≥3 births), body mass index (<30 vs. ≥30 kg/m2), menarche (<13, 13–14, ≥15 years), age at menopause (premenopausal, <45, 45–49, 50–54, ≥55 years), race (white/nonwhite), and smoking status (never, former, current smoker). Unknown/missing was set as a separate category within each factor.
b P value from logistic regression of case-only analysis comparing each risk factor.