Figure 1. Clinical course of ZAP10.
Periods of daclizumab therapy are highlighted in green (NIH clinical trial) and yellow (off-label therapy), while 5-day courses of IV methylprednisolone (MP) are highlighted by blue arrows. Therapy of CNS vasculitis with IV cyclophosphamide (Cytoxan) is highlighted in blue. Longitudinal measurements of Expanded Disability Status Scale (EDSS) (black triangles) and total number of contrast-enhancing lesions (CEL) on brain MRI (red circles) are depicted for a period of 8 years.