Table 2.

(R)-P-catalyzed Asymmetric aza-MBH Reaction

entrya	R1	R2	yield (%)b	ee (%)c
1	1b, 5-CH3	Bn	2b', 93	95
2	1c, 5-F	Bn	2c', 96	93
3	1d, 5-Cl	Bn	2d', 91	99
4	1e, 5-Br	Bn	2e', 97	>99
5	1f, 6-CH3	Bn	2f', 88	99
6	1g, 6-Cl	Bn	2g', 93	96
7	1h, 6-Br	Bn	2h', 93	97
8	1i, 7-F	Bn	2i', 87	95
9	1j, 7-Cl	Bn	2j', 70	99
10	1k, 7-Br	Bn	2k', 78	99
11	1l, 7-CF3	Bn	2l', 70	94
12	1m, 5-Cl, 7-CH3	Bn	2m', 86	>99
13	1n, 4-CH3	Bn	trace	ndd
14	1o, 4,7-Cl2	Bn	trace	ndd
15	1p, H	Me	2p', 85	95
16	1q, H	Allyl	2q', 90	97
17	1r, 5-CH3O	Bn	2r, 83	90
18e	1s, H	Bn	2s, 86	70
19e	1t, 4,7-Cl2	Bn	trace	ndd

^a1 (0.1 mmol), MVK (0.2 mmol) and catalyst (0.02 mmol) were stirred in 2 mL of chloroform within 48 h at rt.

^bIsolated yield.

^cDetermined by chiral HPLC.

^dNot determined.

^et-Bu group of Boc moiety in 1a was replaced by ethyl group.