Table 1.

Biometric and echocardiographic properties in C57 and ETAKO young and old mice

	C57BL/6 Young	C57BL/6 Old	ETAKO Young	ETAKO old
Body Weight (g)	25.3 ± 0.9	29.5 ± 0.5*	25.7 ± 0.8	29.2 ± 0.4*
Heart Weight (mg)	218 ± 14	256 ± 10*	224 ± 14	232 ± 11#
HW/BW (mg/g)	8.60 ± 0.42	8.76 ± 0.41	8.55 ± 0.54	8.01 ± 0.41
Liver Weight (g)	1.32 ± 0.04	1.40 ± 0.03	1.33 ± 0.04	1.41 ± 0.01
LW/BW (mg/g)	48.8 ± 1.3	47.1 ± 1.8	48.8 ± 1.3	48.6 ± 0.8
Kidney Weight (g)	0.39 ± 0.03	0.43 ± 0.01	0.39 ± 0.02	0.40 ± 0.02
KW/BW (mg/kg)	14.3 ± 0.7	14.3 ± 0.6	14.2 ± 0.7	14.1 ± 0.5
Diastolic blood pressure (mmHg)	85.7 ± 2.7	81.3 ± 2.4	84.6 ± 2.6	82.1 ± 1.9
Systolic blood pressure (mmHg)	114.8 ± 2.1	124.7 ± 2.4*	114.3 ± 2.3	122.3 ± 2.1*
Mean blood pressure (mmHg)	95.4 ± 2.0	95.8 ± 1.6	93.8 ± 2.6	95.5 ± 1.3
Plasma ET-1 (pg/ml)	0.96 ± 0.08	2.59 ± 0.20*	0.99 ± 0.11	2.44 ± 0.20*
Plasma Angiotensin II (pg/ml)	105.8 ± 11.0	160.1 ± 12.2*	103.1 ± 7.0	145.5 ± 13.7*
Heart Rate (beat per minute)	453 ± 20	451 ± 23	467 ± 26	442 ± 19
Diastolic Diameter (mm)	2.63 ± 0.14	2.61 ± 0.06	2.68 ± 0.09	2.64 ± 0.05
Systolic Diameter (mm)	1.42 ± 0.08	1.65 ± 0.06*	1.42 ± 0.06	1.45 ± 0.05#
Diastolic Wall Thickness (mm)	0.74 ± 0.05	1.01 ± 0.04*	0.76 ± 0.04	0.80 ± 0.05#
LV Mass (mg)	50.0 ± 5.6	70.5 ± 5.0*	52.0 ± 4.1	57.9 ± 5.0#
Normalized LV Mass (mg/g)	2.07 ± 0.16	2.49 ± 0.19*	2.19 ± 0.13	2.02 ± 0.19#
Fractional Shortening (%)	45.7 ± 1.6	36.7 ± 1.3*	46.7 ± 2.2	44.8 ± 2.3#

HW: heart weight; LW: Liver weight; KW: Kidney weight. Mean ± SEM, n = 13–14 mice per group,

^*p < 0.05 vs. corresponding young group;

^#p < 0.05 vs. C57BL/6 old group.