Table 1. AMD3465 Inhibits Breast Cancer Metastases.
| 4T1 Cell Model | |||||
| PBS Group | AMD3465 Group | ||||
| Animal # | Lung Met. | Liver Met. | Animal # | Lung Met. | Liver Met. |
| 1 | 22 | 110 | 1 | 0 | 0 |
| 2 | 41 | 89 | 2 | 0 | 0 |
| 3 | 17 | 36 | 3 | 0 | 0 |
| 4 | 19 | 26 | 4 | 1 | 0 |
| 5 | 15 | 27 | 5 | 2 | 20 |
| 6 | 10 | 30 | 6 | 0 | 0 |
| 7 | 20 | 46 | 7 | 0 | 0 |
| 8 | 2 | 1 | |||
| 9 | 5 | 0 | |||
| Mean +/− S.D. | 20.8+/−9.8 | 52+/−33.7 | Mean +/− S.D. | 1.1+/−1.7* | 2.3+/−6.6* |
| 4T07 Cell Model | |||||
| PBS Group | AMD3465 Group | ||||
| Animal # | Lung Met. | Animal # | Lung Met. | ||
| 1 | 3 | 1 | 0 | ||
| 2 | 5 | 2 | 1 | ||
| 3 | 6 | 3 | 2 | ||
| 4 | 8 | 4 | 1 | ||
| 5 | 6 | ||||
| Mean +/− S.D. | 5.6+/−1.8 | Mean +/− S.D. | 1.0+/−1** | ||
| 168Farn Cell Model | |||||
| PBS Group | AMD3465 Group | ||||
| Animal # | Lung Met. | Animal # | Lung Met. | ||
| 1 | 4 | 1 | 0 | ||
| 2 | 1 | ||||
| 3 | 6 | ||||
| 4 | 5 | 4 | 3 | ||
| 5 | 4 | 5 | 1 | ||
| Mean +/− S.D. | 4.8+/−1 | Mean +/− S.D. | 1.3+/−0.9** | ||
Site and number of metastases (Met.),
*
p<0.001 and **p<0.01 statically significant differences.