Figure 2. miRNA-mediated cell death network based on literature mining. (A) Most of PCD-associated miRNAs and their targets can be integrated into a big interlocking network. Trianglar and circular nodes represent cell death-associated miRNAs and proteins, respectively. Edges represent the miRNA targeting protein regulation. Apoptotic miRNAs and proteins are in pink, while autophagy-associated ones are in green. Note that yellow-colored miRNAs play dual roles in both apoptosis and autophagy. (B) An example of miRNA hubs in the PCD network. The MIR21 hub targets 8 PCD-related proteins including the BCL2 hub, which is again intensively regulated by 18 miRNAs. (C) An example of miRNAs which potentially mediate the crosstalk between autophagic and apoptotic death modules. The MIR181A2 connects 3 apoptotic proteins (BCL2, BCL2L11 and MCL1) with 1 autophagic protein, ATG5.