Table 1.
Experimental groups for present study showing dose regimens and Mean Survival Time (MST)
| Group n = 10 | G-1 | G-2 | G-3 | G-4 | G-5 | G-6 | G-7 | G-8 | G-9 | G-10 |
|---|---|---|---|---|---|---|---|---|---|---|
| Drug/vehicle 0.2 ml/day/mouse | DW | DW | china ϕ (1:2) | china 30 (1:2) | Absolute alcohol | ASa (100 mg/kg) | 5 % NaHCO3 + 0.9 %NaCl | AS + chinab ϕ | AS + chinab 30 | AS (4 mg/kg) + SP(1.2 mg/kg) |
| MST (days) | 28 ± 0 | 7 ± 0 | 24.5 ± 3.5 | 26.8 ± 1.2 | 5 ± 0 | 28 ± 0 | 6.5 ± 0.5 | 28 ± 0 | 28 ± 0 | 28 ± 0 |
All the groups except G-1 were injected with 1 × 106 infected RBCs on day 0
aAdministered BD on day 0 and OD on D1-D6
bchina was given 1 h after the oral administration of artesunate