Table 3.

Factors influencing telomeric chromatin.

Name	Org.	Binding partners	Function(s)	Reference
ORC	h	Tel-DNA, TERRA; TRF2	DNA replication; inhibition of telomere circle formation	Deng et al. (2007, 2009b)
TERRA	h	TRF1, TRF2, ORC. HP1, H3K9me3	Facilitation of TRF2-ORC interaction; chromatin compaction	Deng et al. (2009b)
ERCC1/XPF	h, m	Tel-DNA	3′-Overhang degradation (in uncapped telomeres)	Zhu et al. (2003), Munoz et al. (2005), Wu et al. (2007b)
53BP1	m	H4K20me2	Promotion of NHEJ; increase of telomere mobility (in dysfunctional telomeres)	Dimitrova et al. (2008)
SHREC	Sp	Ccq1	Regulation of nucleosome positioning; telomeric silencing	Sugiyama et al. (2007)
14-3-3σ	h	nd	Help in DDR (G2 arrest)	Dhar et al. (2000)
DNA-Pkcs	h, m	WRN	B-NHEJ repression; promotion of WRN helicase activity on D-loop; capping	Gilley et al. (2001), Bombarde et al. (2010), Kusumoto-Matsuo et al. (2010)
HP1	h, d, m	H3K9me3, tel-DNA (d)	Transcription repression; capping; chromatin compaction	Lachner et al. (2001), Koering et al. (2002), Garcia-Cao et al. (2004), Perrini et al. (2004)
Cbx1, Cbx3, Cbx5	m	H3K9me3	Chromatin compaction	Garcia-Cao et al. (2004)
Daxx/ATRX	m	H3.3	Deposition of H3.3	Goldberg et al. (2010), Lewis et al. (2010)
ATRX	h, m	mH2A	Inhibition of mH2A1 incorporation; TERRA repression (m)	Ratnakumar et al. (2012)
Rb1, Rbl1, Rbl2	m	HP1, SUV4-20H HMTases	TS and chromatin compaction	Garcia-Cao et al. (2002), Gonzalo and Blasco (2005)
miR-290 (Dicer-dependent)	m	Rbl2 mRNA	Regulation of DNA methylation	Benetti et al. (2008a), Sinkkonen et al. (2008)

org, organism; h, human; m, mouse; Sp, Schizosaccharomyces pombe; d, Drosophila melanogaster; nd, not determined; tel-DNA, telomeric DNA; TERRA, telomeric repeat-containing RNA; NHEJ, non-homologous end-joining (B, backup; C, classical); DDR, DNA damage response; TS, telomere shortening.