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. 2013 Feb 5;98(3):E600–E604. doi: 10.1210/jc.2012-3644

Table 1.

Single-SNP Association Studies of the 24 tagSNPs in the PPARG Gene With T2D Risk Under Additive Model in WHI-OS Nested Case-Control Sample (n = 3713)a

dbSNP ID European American (954/968)b African American (369/754) Hispanic American (141/282) Asian American (79/166) Combined (1543/2170) P Value (Combined)
rs9878908 0.85 (0.55–1.32) 0.75 (0.35–1.61) 1.18 (0.45–3.06) 1.00 (0.62–1.60) 0.89 (0.65–1.21) .46
rs6798713 0.75 (0.47–1.17) 0.98 (0.57–1.67) 1.40 (0.52–3.74) 1.06 (0.67–1.67) 0.89 (0.66–1.20) .44
rs6809631 0.71 (0.46–1.10) 0.78 (0.50–1.23) 0.66 (0.32–1.38) 0.80 (0.48–1.34) 0.76 (0.58–0.99) .04c
rs9817428 0.76 (0.49–1.17) 0.80 (0.53–1.21) 0.66 (0.32–1.37) 0.78 (0.47–1.30) 0.78 (0.60–1.00) .05d
rs10510411 0.68 (0.44–1.06) 0.64 (0.37–1.11) 0.78 (0.38–1.60) 1.06 (0.66–1.71) 0.68 (0.52–0.91) .01e
rs12629293 0.66 (0.43–1.04) 0.78 (0.49–1.24) 0.78 (0.38–1.58) 1.05 (0.65–1.70) 0.72 (0.55–0.94) .02f
rs12636454 0.68 (0.44–1.06) 0.79 (0.52–1.21) 0.76 (0.37–1.54) 1.10 (0.69–1.76) 0.73 (0.57–0.95) .02g
rs4518111 1.36 (0.91–2.03) 1.06 (0.65–1.75) 1.40 (0.70–2.82) 1.18 (0.74–1.89) 1.20 (0.94–1.54) .15
rs10510418 1.12 (0.74–1.69) 0.75 (0.43–1.33) 0.91 (0.40–2.06) 0.69 (0.38–1.27) 1.03 (0.79–1.36) .81
rs1801282 0.62 (0.35–1.12) 0.59 (0.15–2.31) 0.27 (0.08–0.93)h 0.21 (0.04–1.04) 0.55 (0.35–0.86) .01i
rs1373640 1.17 (0.79–1.75) 0.86 (0.49–1.49) 1.14 (0.53–2.46) 0.56 (0.27–1.12) 1.11 (0.84–1.45) .46
rs2972162 1.23 (0.82–1.84) 1.19 (0.79–1.80) 1.02 (0.51–2.04) 0.98 (0.58–1.67) 1.17 (0.92–1.48) .20
rs10510419 1.45 (0.83–2.54) 1.25 (0.69–2.26) 0.98 (0.39–2.45) 1.49 (0.19–11.51) 1.22 (0.86–1.72) .26
rs2959272 1.22 (0.82–1.83) 1.12 (0.75–1.68) 0.99 (0.49–2.00) 1.08 (0.64–1.80) 1.15 (0.91–1.46) .24
rs709150 0.67 (0.44–1.03) 0.80 (0.48–1.31) 0.99 (0.50–1.96) 0.94 (0.56–1.57) 0.80 (0.62–1.03) .08
rs709157 1.32 (0.88–1.98) 0.67 (0.34–1.31) 0.96 (0.44–2.06) –j 1.08 (0.81–1.43) .61
rs1175540 1.12 (0.76–1.65) 1.04 (0.68–1.60) 0.97 (0.46–2.03) 1.18 (0.69–2.02) 1.08 (0.85–1.37) .53
rs1175544 1.21 (0.82–1.79) 0.81 (0.45–1.47) 0.99 (0.45–2.17) 1.25 (0.74–2.10) 1.11 (0.85–1.44) .44
rs1797912 1.18 (0.80–1.74) 0.91 (0.56–1.49) 1.09 (0.49–2.45) 1.00 (0.60–1.65) 1.12 (0.86–1.44) .40
rs1152002 0.93 (0.64–1.37) 0.94 (0.62–1.43) 2.01 (0.92–4.41) 0.84 (0.51–1.37) 1.06 (0.83–1.35) .65
rs3856806 0.93 (0.50–1.71) 0.52 (0.22–1.22) 0.31 (0.09–1.07) 0.83 (0.47–1.48) 0.71 (0.48–1.07) .10
rs1152003 1.09 (0.73–1.63) 0.96 (0.65–1.41) 1.72 (0.84–3.50) 1.01 (0.62–1.64) 1.07 (0.85–1.36) .56
rs1152007 1.15 (0.74–1.81) 0.74 (0.45–1.24) 1.10 (0.46–2.64) 0.88 (0.56–1.37) 0.92 (0.70–1.21) .55
rs709167 1.06 (0.73–1.55) 1.09 (0.66–1.79) 1.12 (0.49–2.54) 0.86 (0.47–1.57) 1.06 (0.82–1.36) .68
a

Adjusted OR (95% CI) for each tagSNP was estimated under the additive genetic model, using conditional logistic regression models with adjustments for age, body mass index, ln(fasting insulin), ln(fasting glucose), cigarette smoking (never, past, and current), alcohol intake (never, past, and current), hormone replacement therapy usage (never, past, and current), T2D family history (presence/absence), and physical activity per week at baseline. Due to the small Asian population size, body mass index, ln(fasting insulin), and ln(fasting glucose) were excluded to cause the model to converge. Confirmatory T2D association results for rs9817428 and rs1801282 (both highlighted) under an additive model in WHI-SHARe case-control sample are shown in Supplemental Table 5. Associations with FDR-adjusted P ≤ .05 are shown in bold.

b

Sample size is presented as cases/controls.

c

P = .04, with FDR-adjusted P = .19 using the method of Benjamini and Hochberg.

d

P = .05, with FDR-adjusted P = .21 using the method of Benjamini and Hochberg.

e

P = .01, with FDR-adjusted P = .11 using the method of Benjamini and Hochberg.

f

P = .02, with FDR-adjusted P = .12 using the method of Benjamini and Hochberg.

g

P = .02, with FDR-adjusted P = .12 using the method of Benjamini and Hochberg.

h

P = .04, with FDR-adjusted P = .65 using the method of Benjamini and Hochberg.

i

P = .01, with FDR-adjusted P = .11 using the method of Benjamini and Hochberg.

j

Result is difficult to interpret because of small sample size within stratum.