Table 1.
Marrow Adiposity and Skeletal Phenotype of Animal Models Discussed in This Review
| Mouse Model | Marrow Adiposity | Skeletal Phenotype: Bone Volume Fraction in the Distal Femur (Ref.) |
|---|---|---|
| C3H/HeJ | Increased | High cortical; normal trabecular [low vertebral] (60) |
| C57BL/6J | Reduced | Normal |
| Rosiglitazone treatment | Increased | Low in some strains of mice tested (60, 62) |
| 11 β OHase null (−/−) | None | Normal |
| Ebf1 null (−/−) | Increased | High early then subsequently low (32) |
| Glucocorticoid treatment | Increased or unchanged | Low (99) |
| Wnt10b overexpression in bone (osteocalcin promoter) | Reduced | High (100) |
| Small (Irs1 mutant) | None | Low (76) |
| Little (ghrh-deficient) | Increased | Low (80) |
| LID (targeted Igf-I liver-deficient) | Normal | Low (80) |
| Calorie restriction, C57BL/6 mice- young | Increased | Low (14, 15) |
| High-fat diet, C57BL/6 | Normal to increased | Normal to slightly low (15) |
| Ob/Ob (leptin deficient) | Increased | Low in femur; high in vertebrae (70) |
| C57BL/6 ovariectomy | Increased | Low (80) |
| Igfbp2 null −/− | Increased | Low (101) |
| Lactation at day 7, C57BL/6 | Reduced | Low (C.J.R., unpublished observation) |
| aP2-FoxC2 Tg, overexpression of FoxC2 in adipose cells | Increased | Increased (Beata Lecka-Czernik, PhD, unpublished observation) |
| Insulin deficiency, diabetes mellitus C57BL/6 | Increased | Decreased (57) |
| Insulin resistance, C57BL/6 | Normal to increased | Normal to slightly low (15) |
| Lrp5, High bone mass gene Tg (overexpression) | Reduced | Increased (102) |
| Lrp5-deficient mice | Increased | Decreased (103) |
| BADGE treatment (PPARγ antagonist) | Decreased | Unchanged or increased (104) |
| Radiation (therapeutic or ablative) | Increased | Reduced (105) |
| A-Zip | Reduce | High |