Figure 7. Representative structure of Et-KuQ docked on the covalent Top1+DNA binary complex.

The Et-KuQ is represented in cyan; the lateral chains of the residues of the catalytic pentad and of the Asn⁷²² are represented as sticks and labelled, the rest of the protein is represented as ribbon. The base-pairs in position +1 and −1 are represented in black. A blue dashed line indicates the distance between the 5′ DNA end, represented as a red sphere and the closest Et-KuQ oxygen acceptor.