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. 2013 Mar 2;10(4):441–450. doi: 10.7150/ijms.5765

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© Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.

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Fig 1 — Masson Trichrome and Hematoxylin-Eosin staining observed in rat liver tissue. (original magnification 40 X). (A)Negative control: Normal liver; (B) Positive control : liver fibrosis was induced by intraperitoneal injection with 0.5ml/kg weight porcine serum twice weekly for 8 weeks. Pictures were taken under at different time points. Week 2: Hepatic interstitial proliferation and fibrosis; Week 6: Septal fibrosis; Week 8: Massive fibrous proliferation in liver, pseudo-lobules and early nodular cirrhosis; (C) early-stage rhBMP-7 treatment; (D) late-stage treatment; (E) prophylactic.