Table 3.

Main results of pooled odds ratios (ORs) with confidence intervals (CI) in the meta-analysis for rs2234693.

Allele contrasts in different genetic models	Pool OR (95% CI)	P-value for Z test	I2 for heterogeneity (%)	P-value for heterogeneity
rs2234693 (Overall)
Dominant (CC+TC allele vs. TT allele)	Random effects 1.35 (1.01, 1.81)	0.05	72	0.0003
Recessive (CC allele vs. TC + TT allele)	Fixed effects 1.40 (1.15, 1.69)	0.0007	11	0.34
Additive (CC allele vs. TT allele)	Random effects 1.67 (1.19, 2.34)	0.003	52	0.03
Co-dominant (TC allele vs. TT + CC allele)	Random effects 1.04 (0.85, 1.27)	0.71	44	0.06
allele contrast (C allele vs. T allele)	Random effects 1.09 (0.88, 1.36)	0.43	76	0.0001
rs2234693 (Female)
Dominant (CC+TC allele vs. TT allele)	Random effects 0.70 (0.41, 1.20)	0.20	59	0.04
Recessive (CC allele vs. TC + TT allele)	Fixed effects 0.82 (0.53, 1.25)	0.35	9	0.36
Additive (CC allele vs. TT allele)	Random effects 1.05 (1.19, 2.34)	0.92	65	0.02
Co-dominant (TC allele vs. TT + CC allele)	Random effects 1.15 (0.69, 1.90)	0.60	57	0.05
allele contrast (C allele vs. T allele)	Random effects 170 (0.98, 2.94)	0.47	66	0.02
rs2234693 (Male)
Dominant (CC+TC allele vs. TT allele)	Random effects 1.22 (0.71, 2.11)	0.47	66	0.03
Recessive (CC allele vs. TC + TT allele)	Fixed effects 1.62 (1.10, 2.39)	0.01	34	0.21
Additive (CC allele vs. TT allele)	Random effects 1.94 (0.93, 4.03)	0.08	57	0.07
Co-dominant (TC allele vs. TT + CC allele)	Fixed effects 0.86 (0.65, 1.16)	0.32	10	0.34
allele contrast (C allele vs. T allele)	Random effects 1.29 (0.88, 1.90)	0.20	67	0.03