Table 5.

Sensitivity analysis of the ESR1 rs2234693 and rs9340799 polymorphisms and CHD under an additive model.

Excluded study characteristic	included studies	Excluded studies	Pooled ORs (95%)	P-value	I2 (%)	P-value for heterogeneity
rs2234693
	19, 29-37	none	Random effects 1.67 (1.19, 2.34)	0.003	52	0.03
	19, 29-36	37	Random effects 1.72 (1.14, 2.60)	0.009	58	0.02
	19, 29-35, 37	36	Random effects 1.60 (1.12, 2.30)	0.01	54	0.03
	19, 29-34, 36, 37	35	Random effects 1.79(1.24, 2.58)	0.002	54	0.03
	29-37	19	Random effects 1.66 (1.14, 2.42)	0.008	57	0.02
	19, 29-33, 35-37	34	Random effects 1.75 (1.21, 2.54)	0.003	57	0.02
	19, 29-32, 34-37	33	Random effects 1.78 (1.22, 2.60)	0.003	55	0.02
	19, 29-31, 33-37	32	Random effects 1.65 (1.16, 2.36)	0.006	52	0.02
	19, 29, 30, 32-37	31	Random effects 1.80 (1.30, 2.51)	0.0004	52	0.06
	19, 29, 31-37	30	Random effects 1.51 (1.13, 2.02)	0.006	52	0.08
	19, 30-37	29	Random effects 1.54 (1.12, 2.13)	0.009	52	0.06
rs9340799
	19, 31-37	none	Fixed effects 1.08 (0.86, 1.38)	0.5	0	0.64
	19, 31-36	37	Fixed effects 1.00 (0.71, 1.40)	0.99	0	0.59
	19, 31-35, 37	36	Fixed effects 1.08 (0.85, 1.37)	0.54	0	0.53
	19, 31-34, 36, 37	35	Fixed effects 1.11 (0.86, 1.42)	0.78	0	0.55
	31-37	19	Fixed effects 1.12 (0.86, 1.46)	0.4	0	0.56
	19, 31-33, 35-37	34	Fixed effects 1.13 (0.89, 1.45)	0.32	0	0.80
	19, 31, 32, 34-37	33	Fixed effects 1.07 (0.84, 1.36)	0.57	0	0.58
	19, 31, 33-37	32	Fixed effects 1.06 (0.84, 1.35)	0.62	0	0.81
	19, 32-37	31	Fixed effects 1.08 (0.85, 1.38)	0.54	0	0.53

OR: odds ratio; CI: confidence interval.