Table 7.
Transcription factors associated with developmental competence of oocytes found by meta-analysis of previously published microarray studies comparing in vivo and in vitro matured oocytes in bovine and monkey, human healthy and polycystic ovaries (PCOS-polycystic ovary syndrome), and mouse young and aged ovaries [38].
| Transcripts associated with developmental competence of oocytes | |||
|---|---|---|---|
| Increased developmental competence | Decreased developmental competence | ||
| CPD | Carboxypeptidase D precursor | PRKG1 | cGMP-dependent protein kinase 1, alpha isozyme |
| SH3BGRL | SH3 domain binding glutamic acid-rich-like protein | IGFBP3 | Insulin-like growth factor binding protein 3 |
| CDC123 | Cell division cycle 123 | DUSP1 | Dual specificity phosphatase 1 |
| AQP1 | Aquaporin 1 | NDRG4 | Ndr4 |
| GNB5 | Guanine nucleotide binding protein beta 5 | ATOX1 | Copper transport protein |
| METAP2 | Methionine aminopeptidase 2 | TMSB10 | Thymosin beta-10 |
| UBE2E3 | Ubiquitin-conjugating enzyme E2E3 | ATRX | Alpha thalassemia/mental retardation syndrome X-linked |
| USP6NL | USP6 N-terminal-like protein | SHMT2 | Serine hydroxymethyltransferase 2 |
| HMGA1* | High Mobility group AT-hook1 | TGFBR3* | Transforming growth factor beta receptor III |
| TCTEL1 | TCTEL1 protein | FANK1 | Fibronectin type 3 and ankyrin repeat domains 1 protein |
| SNRPD3 | Small nuclear ribonucleoprotein D3 polypeptide | PTPN1 | Protein tyrosine phosphatase, nonreceptor type 1 |
| MTG1 | Mitochondrial GTPase 1 homolog | DDX55 | ATP-dependent RNA helicase DDX55 |
| GKAP1 | G kinase anchoring protein 1 | SFRP1* | Secreted frizzled-related protein 1 |
| UFM1 | Ubiquitin-fold modifier 1 | BMP4 | Bone morphogenetic protein 4 |
| MITD1 | Mitochondria interacting transport domain 1 |
HIST1HBG | Histone H2B type 1-C/E/G |
| MRPL3 | Mitochondrial ribosomal protein L3 | SEC61G | Protein transport protein Sec61 subunit gamma |
| KIF23 | Kinesin family member 23 | FOXM1* | Forkhead box protein M1 |
| DDX52 | DEAD box polypeptide 52 | NDUFA1 | NADH dehydrogenase 1 alpha subcomplex subunit 1 |
| TUSC4 | Tumor suppressor candidate 4 | ||
| JMJD1C | Jumonji domain containing 1C | ||
| POL2RL | DNA-directed RNA polymerases I, II, and III subunit RPABC5 | ||
| MED1 | Mediator complex subunit 1 | ||
| SLC39A14 | Solute carrier family 39 member 14 | ||
| CALM2 | Calmodulin 2 | ||
| RPS18 | 40S ribosomal protein S18 | ||
| INVS | Inversion | ||
| RBMS1 | RNA binding motif single stranded interacting protein 1 | ||
| PLXNC1 | Plexin C1 | ||
| BTF3l4 | Basic transcription factor 3-like 4 | ||
| MAP3K12* | Mitogen-activated protein 3 kinase 12 | ||
| PXMP4 | Peroxisomal membrane protein 4 | ||
| EG216818 | Ubiquitin | ||
| JAM2 | Junctional adhesion molecule 2 | ||
| IFITM1 | Interferon-induced transmembrane protein 1 | ||
| LRRC28 | Leucine rich repeat containing 28 | ||
|
| |||
| Transcription regulation | |||
| Associated with decreased competence in oocytes | |||
|
| |||
| E2f4 65 | |||
| Sp3 61 | |||
| Gata-1 62 | |||
| C/ebp β 62 | |||
| Rela (P65 NF-Kb Subunit) | |||
*Potential biomarkers of oocyte developmental competence.