Table 3. Excess hazard ratios of death for country of residence during the first year since diagnosis, colorectal cancer, 1997–2004.
| |
|
|
Multiple imputations for missing values |
Complete case analysisa |
||||||
|---|---|---|---|---|---|---|---|---|---|---|
| N | Variable | EHR | 95% CI | P-values | EHR | 95% CI | P-values | |||
|
Colon cancer | ||||||||||
|
Model 1 | ||||||||||
| |
Countries |
England |
1.00 |
|
|
<0.001 |
1.00 |
|
|
<0.001 |
| |
|
France |
0.70 |
0.66 |
0.75 |
|
0.73 |
0.68 |
0.78 |
|
| Model 2 |
=Model 1+age, sex, period |
|
|
|
|
|
|
|
|
|
| |
|
England |
1.00 |
|
|
<0.001 |
1.00 |
|
|
<0.001 |
| |
|
France |
0.70 |
0.65 |
0.74 |
|
0.73 |
0.68 |
0.78 |
|
| Model 3 |
=Model 2 +cancer localisationa |
|
|
|
|
|
|
|
|
|
| |
|
England |
1.00 |
|
|
<0.001 |
1.00 |
|
|
<0.001 |
| |
|
France |
0.70 |
0.65 |
0.74 |
|
0.81 |
0.75 |
0.86 |
|
| Model 4 |
=Model 3 +stage |
|
|
|
|
|
|
|
|
|
| |
|
England |
1.00 |
|
|
<0.001 |
1.00 |
|
|
<0.001 |
| |
|
France |
0.68 |
0.64 |
0.74 |
|
0.75 |
0.70 |
0.80 |
|
| Model 5a |
=Model 2 for Duke's A & B only |
|
|
|
|
|
|
|
|
|
| |
|
England |
1.00 |
|
|
0.006 |
1.00 |
|
|
0.033 |
| |
|
France |
0.77 |
0.65 |
0.93 |
|
0.79 |
0.66 |
0.95 |
|
| Model 6a |
=Model 5a for Duke's A & B+resection within 6 months |
|
|
|
|
|
|
|
|
|
| |
|
England |
1.00 |
|
|
0.038 |
1.00 |
|
|
0.038 |
| |
|
France |
0.82 |
0.68 |
0.99 |
|
0.82 |
0.68 |
0.98 |
|
| Model 5b |
=Model 3 for Duke's C & D cancer only |
|
|
|
|
|
|
|
|
|
| |
|
England |
1.00 |
|
|
<0001 |
1.00 |
|
|
<0.001 |
| |
|
France |
0.67 |
0.63 |
0.72 |
|
0.74 |
0.69 |
0.80 |
|
| Model 6b |
=Model 5b for Duke's C & D cancer only+resection within 6 months |
|
|
|
|
|
|
|
|
|
| |
|
England |
1.00 |
|
|
<0.001 |
1.00 |
|
|
<0.001 |
| |
|
France |
0.79 |
0.74 |
0.85 |
|
0.83 |
0.77 |
0.90 |
|
| Model 7b |
=model 5b for Duke's C & D cancer only+resection within 6 months+chemotherapy |
|
|
|
|
|
|
|
|
|
| |
|
England |
1.00 |
|
|
0.095 |
1.00 |
|
|
0.862 |
| |
|
France |
0.94 |
0.88 |
1.01 |
|
1.00 |
0.92 |
1.06 |
|
| Model 8b |
=Model 5b for Duke's C & D cancer only+resection within 6 months+chemotherapy+interaction (countries-chemotherapy) |
|
|
|
|
|
|
|
|
|
| Without chemotherapy |
|
England |
1.00 |
|
|
0.918 |
1.00 |
|
|
0.082 |
| |
|
France |
0.99 |
0.92 |
1.07 |
|
1.07 |
0.99 |
1.17 |
|
| With chemotherapy |
|
England |
1.00 |
|
|
0.008 |
1.00 |
|
|
0.001 |
| |
|
France |
0.81 |
0.69 |
0.94 |
|
0.76 |
0.65 |
0.89 |
|
|
Rectum cancer | ||||||||||
| Model 9 |
|
England |
1.00 |
|
|
<0.001 |
1.00 |
|
|
<0.001 |
| |
|
France |
0.76 |
0.68 |
0.86 |
|
0.74 |
0.64 |
0.85 |
|
| Model 10 |
=Model 9+age, sex, period |
|
|
|
|
|
|
|
|
|
| |
|
England |
1.00 |
|
|
<0.001 |
1.00 |
|
|
<0.001 |
| |
|
France |
0.76 |
0.67 |
0.85 |
|
0.73 |
0.63 |
0.84 |
|
| Model 11 |
=Model 10+stage |
|
|
|
|
|
|
|
|
|
| |
|
England |
1.00 |
|
|
<0.001 |
1.00 |
|
|
<0.001 |
| |
|
France |
0.69 |
0.61 |
0.77 |
|
0.67 |
0.58 |
0.77 |
|
| Model 11a |
=Model 10 for duke's A & B cancer only |
|
|
|
|
|
|
|
|
|
| |
|
England |
1.00 |
|
|
0.048 |
1.00 |
|
|
0.065 |
| |
|
France |
0.70 |
0.49 |
0.99 |
|
0.71 |
0.50 |
1.02 |
|
| Model 12a |
=Model 10 for Duke's A & B cancer only+resection within 6 months |
|
|
|
|
|
|
|
|
|
| |
|
England |
1.00 |
|
|
0.13 |
1.00 |
|
|
0.353 |
| |
|
France |
0.74 |
0.51 |
1.08 |
|
0.83 |
0.57 |
1.22 |
|
| Model 11b |
=Model 10 for Duke's C & D cancer only |
|
|
|
|
|
|
|
|
|
| |
|
England |
1.00 |
|
|
<0.001 |
1.00 |
|
|
<0.001 |
| |
|
France |
0.69 |
0.61 |
0.77 |
|
0.66 |
0.57 |
0.77 |
|
| Model 12b |
=Model 11a for Duke's C & D cancer only+resection within 6 months |
|
|
|
|
|
|
|
|
|
| |
|
England |
1.00 |
|
|
<0.001 |
1.00 |
|
|
<0.001 |
| |
|
France |
0.73 |
0.64 |
0.82 |
|
0.77 |
0.66 |
0.89 |
|
| Model 13b |
=Model 11a for Duke's C & D cancer only+resection within 6 months+radiotherapy+chemotherapy |
|
|
|
|
|
|
|
|
|
| |
|
England |
1.00 |
|
|
0.575 |
1.00 |
|
|
0.637 |
| France | 0.96 | 0.85 | 1.09 | 1.01 | 0.86 | 1.10 | ||||
Abbreviations: CI=confidence interval; EHR=excess hazard ratio.
a
Unknown Colon Cancer (C18.8 or C18.9) was kept in complete case analysis.