Figure 2.

Tumour uptake of E6-binding mAb ¹⁸⁸Re-C1P5 in nude mice-bearing CasKi and 2A3 tumours post treatment with cisplatin. Mice were treated with various doses of cisplatin for 3 days, ¹⁸⁸Re-C1P5 mAb was administered 24 h after the last dose of cisplatin, and the tumour uptake was assessed 24 h post ¹⁸⁸Re-C1P5 administration: (A) CasKi; (B) 2A3; (C, D) TUNEL staining of the untreated and cisplatin-treated tumours. Apoptotic cells stained brown. Original magnification × 400: (C) CasKi tumours—untreated (left panel) and treated with 5 mg kg⁻¹ cisplatin (right panel); (D) 2A3 tumours—untreated (left panel) and treated with 5 mg kg⁻¹ cisplatin (right panel).