Table 2.
List of top 15 differentially methylated autosomal genes in amnion tissues from term (TNL, TL) and preterm (PTL) deliveries ranked by statistical significance1.
| TNL versus TL2 | TL versus PTL3 | ||||
|---|---|---|---|---|---|
| Gene | Locus | CpG island4 | Gene | Locus | CpG island4 |
| IL32 | 16p13.3 | No | TOB1 | 17q21 | No |
| EDARADD | 1q42.3 | No | PNPLA3 | 22q13.31 | No |
| STK19 | 6p21.3 | No | ZNF671 | 19q13.43 | No |
| EXTL1 | 1p36.1 | No | DAB2IP 7 | 9q33.1–q33.3 | No |
| HLA-DQB2 | 6p21 | No | MFNG | 22q12 | No |
| MFSD3 | 8q24.3 | Yes | UCN | 2p23–p21 | Yes |
| RAB31 | 18p11.3 | Yes | EXOC3L2 | 19q13.32 | Yes |
| PNPLA3 | 22q13.31 | No | SLC44A2 | 19p13.1 | Yes |
| GRHPR | 9q12 | Yes | FBXL19-AS1 6 | 16p11.2 | Yes |
| MPHOSPH10 | 2p13.3 | No | DLGAP5 | 14q22.3 | Yes |
| PEG10 5 | 7q21 | No | SLC30A3 | 2p23.3 | Yes |
| DSCR10 6 | 21q22.13 | No | CHFR | 12q24.33 | No |
| SRRD | 22q12.1 | Yes | C11orf1 | 11q23.1 | No |
| POLI | 18q21.1 | Yes | SLC24A4 | 14q32.12 | No |
| OSTalpha | 3q29 | No | PI4KB | 1q21 | No |
1Statistical significance was determined based on P-values calculated from DiffScores. All genes listed here have a DiffScore >40 (corresponding to P-value of <0.0001).
2Genes most highly methylated in the TL group compared to the TNL group.
3Genes most highly methylated in the PTL group compared to the TL group.
4Defined by the CpG island track in the UCSC Genome Browser.
5An imprinted gene.
6Non-protein coding genes.
7A gene identified as having three non-island CpG sites with a DiffScore >40.
Abbreviations: TNL: term no labor; TL: term labor; PTL: preterm labor.