Table 1.
Endogenous activators of Nalp3 inflammasome
| Activator | Signal 1 | Signal 2 | Mechanism | Clinic Relevance | Reference (PMID) |
|---|---|---|---|---|---|
| Palmitate | √ | ROS | Metabolic Syndrome | 21478880 | |
| Ceramide | √ | √ | ROS | Metabolic Syndrome | 21217695 |
| Glucose | √ | √ | ROS | Metabolic Syndrome | 20023662 |
| oxLDL | √ | √ | ROS | Metabolic Syndrome | 20428172 |
| Cholesterol Crystals | √ | Lysosomal Damage | Metabolic Syndrome | 20428172 | |
| Islet Amyloid Polypeptide | √ | Lysosomal Damage | Metabolic Syndrome | 20835230 | |
| Monosodium Urate (Uric Acid) | √ | Particle Endocytosis | Gout | 16407889 | |
| Calcium Pyrophosphate Dihydrate (CPPD) | √ | Particle Endocytosis | Pseudogout | 16407889 | |
| Amyloid β | √ | Lysosomal Damage | Alzheimer's Disease | 18604209 | |
| Hyaluronan | √ | Particle Endocytosis | Injure | 19258328 | |
| ATP | √ | K+ Efflux | Injure | 16407890 |