Skip to main content
. Author manuscript; available in PMC: 2013 Jul 1.
Published in final edited form as: Front Biosci (Landmark Ed). 2013 Jan 1;18:638–649. doi: 10.2741/4127

Table 2.

Inflammasome components and atherosclerosis

Inflammasome
Components		 Animal
Genotype		 Genomic
Background		 Age
(weeks)		 High Fat Fed
(weeks)		 Gender Atherosclerosis
Lesion		 References
(PMID)
NLRP3 NLRP3−/−
/ApoE −/−
LDLr−/−x BMT
NLRP3−/− * 		C57BL/6
C57BL/6		 15
16		 11
8		 Not
Specified
Female		 No Difference
Decrease		 21451572
20428172
Caspase-1 Caspase-1−/−
/ApoE −/−
Caspase-1−/−
/ApoE −/−		 C57BL/6
C57BL/6		 16
15		 8
11		 Both
Male and
Female
Not
Specified		 Decrease
No Difference		 22265992
21451572
ASC ASC−/−/ApoE −
/−
LDLr−/−x BMT
ASC−/−		 C57BL/6
C57BL/6		 15
16		 11
8		 Not
Specified
Female		 No Difference
Decrease		 21451572
20428172
IL-1β IL-1β −/−/ApoE
−/−
LDLr−/−x BMT
IL-1β−/−		 DBA/1
C57BL/6J
C57BL/6		 24
16		 0
8		 Male
Female		 Decrease
Decrease		 12615675
20428172
IL-18 IL-18−/−/ApoE
−/−		 C57BL/6 24 0 Male Decrease 12829194
*

BMT: Bone Marrow Transplantation