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. Author manuscript; available in PMC: 2013 Mar 7.
Published in final edited form as: Biochem Soc Trans. 2012 Feb;40(1):31–36. doi: 10.1042/BST20110608

Figure 1. Juxtacrine signalling via the ATX–LPA receptor axis.

Figure 1

ATX secreted from the tumour cell can be captured at the cell surface through binding to β3 integrin in the vicinity of the LPA GPCR. Activation of the LPA GPCR elicits responses that modulate the biological properties of the cancer cell.