Table 1. Incubation time in the wild-type mice panel.

C57 (Prnp^aa), VM (Prnp^bb) and CVF1 (Prnp^a/b) mice were challenged with brain homogenates from 129, G1, G2 or G3 mice previously infected with 79A, ME7 or 301C (Tuzi et al, 2008). The incubation period was measured as the number of days (±s.e.m.) between prion challenge and appearance of clinical signs of disease.

^aOne mouse from this group was diagnosed positive for TSE disease. It was culled 341 days post injection. Eight other mice in this group survived beyond 341 days (432–670 days) without showing clinical or pathological signs of TSE infection.

^bThe donor mouse for this passage was culled 722 days post injection without showing clinical signs of TSE disease. It had pathological signs of TSE infection.