Skip to main content
. 2013 Feb 19;3(2):e231. doi: 10.1038/tp.2013.4

Figure 4.

Figure 4

Systemic administration of SAHA reduces alcohol seeking, but not sucrose seeking, in rats. (a–c) Rats underwent the same alcohol administration paradigm as described in the legend of Figure 3. Two hours before the beginning of the single extinction session, rats received an intraperitoneal (i.p.) administration of vehicle (Veh) or 50 mg/kg SAHA. (a) Number of lever presses during a 30-min extinction session. (b) Cumulative mean presses in bins of 2 min, indicative of the rate of alcohol-associated lever presses during a 30-min extinction session. (c) Latency to the third alcohol-associated lever presses. Results are expressed as mean±s.e.m., **P<0.01 compared with vehicle. (a–c) n=6 per group. (d) Rats trained to self-administer 1.5% sucrose under an FR3 schedule (30-min) received an i.p. administration of vehicle (Veh) or 50 mg/kg SAHA 2 h before the beginning of the first extinction session. Data represent the number of lever presses during the 30-min extinction session. Results are expressed as mean±s.e.m. Veh n=6 and SAHA n=7.