Figure 8.
Schematic representation of LPA-LPAR1/3 Gαi2–mediated activation of p130Cas in cell migration. LPA stimulates the phosphorylation at Tyr-410 of p130Cas via Gαi2 in a Src-dependent pathway, and p130Cas is critically required for LPA-mediated invasive migration of ovarian cancer cells. The blue arrows indicate the results derived from previous studies (see text), whereas the black arrows indicate the results obtained from the present study. Taken together with the previous findings, it can be envisioned that LPA, through distinct LPA receptors, regulates the coordinated signaling of spatially and/or temporally compartmentalized Gαi2-p130Cas–mediated stimulation of Rac as well as Gα13-Rho-GEF–mediated activation of Rho to promote invasive migration of ovarian cancer cells.