Table 1.
Hemodynamics in control and sabiporide-treated rats.
| Baseline | After 5 min drug treatment | Occlusion 30 min | Reperfusion | ||
|---|---|---|---|---|---|
| 1 h | 2 h | ||||
| MBP (mmHg) | |||||
| Control | 119.1 ± 6.5 | 114.2 ± 8.5 | 65.9 ± 3.9# | 69.8 ± 4.5# | 67.6 ± 5.1# |
| Sabiporide (0.01 mg/kg Pre-Isch) | 115.6 ± 8.1 | 122.3 ± 7.6 | 70.1 ± 4.5# | 67.3 ± 5.2# | 70.4 ± 6.4# |
| Sabiporide (0.1 mg/kg Pre-Isch) | 120.8 ± 9.3 | 118.9 ± 10.6 | 68.4 ± 5.3# | 65.3 ± 5.3# | 66.9 ± 5.6# |
| Sabiporide (1 mg/kg Pre-Isch) | 113.4 ± 8.7 | 117.8 ± 7.9 | 68.5 ± 4.9# | 69.2 ± 7.1# | 67.3 ± 5.1# |
| Sabiporide (3 mg/kg Pre-Isch) | 121.8 ± 7.9 | 120.3 ± 8.4 | 72.4 ± 6.1# | 67.2 ± 5.8# | 71.2 ± 6.6# |
| Sabiporide (1 mg/kg Pre-Rep) | 114.5 ± 6.7 | 115.4 ± 6.8 | 66.1 ± 3.5# | 64.5 ± 5.5# | 71.3 ± 5.3# |
|
| |||||
| HR (bpm) | |||||
| Control | 428.1 ± 18.5 | 423.7 ± 25.1 | 323.0 ± 22.4# | 337.3 ± 20.2# | 330.1 ± 23.1# |
| Sabiporide (0.01 mg/kg Pre-Isch) | 416.7 ± 20.5 | 423.6 ± 22.7 | 315.6 ± 20.3# | 323.4 ± 19.7# | 330.5 ± 23.5# |
| Sabiporide (0.1 mg/kg Pre-Isch) | 423.7 ± 23.7 | 416.4 ± 19.9 | 324.9 ± 18.6# | 321.7 ± 23.4# | 319.7 ± 19.5# |
| Sabiporide (1 mg/kg Pre-Isch) | 430.3 ± 21.8 | 425.7 ± 21.6 | 310.5 ± 18.4# | 332.9 ± 21.7# | 324.6 ± 17.8# |
| Sabiporide (3 mg/kg Pre-Isch) | 411.7 ± 19.2 | 419.3 ± 22.5 | 304.7 ± 17.9# | 326.8 ± 19.7# | 321.8 ± 21.9# |
| Sabiporide (1 mg/kg Pre-Rep) | 431.2 ± 20.7 | 420.2 ± 17.7 | 326.6 ± 24.3# | 312.5 ± 18.5# | 323.7 ± 21.2# |
All values are the mean ± SEM, n = 6. # P < 0.05 versus the baseline values.