Table 1.
Protective efficacy induced by pVAX1/SjTGR in mice.
| Groups | Worm reduction | Egg reduction | ||
|---|---|---|---|---|
| Worm burden (mean ± SE) |
Percent reduction in worm burden (%)a | Liver egg per gram (EPG) (mean ± SE) | Percent reduction in liver egg count (%)b | |
| Trail 1 | ||||
| pVAX1/SjTGR/g.g. (n = 10)c | 15.6 ± 8.86* | 27.83 | 31591.3 ± 14647.42* | 40.38 |
| pVAX1/g.g. (n = 10) | 23.3 ± 6.85 | −8.03 | 42995.7 ± 11730.94 | 18.86 |
| pVAX1/SjTGR/i.m. (n = 10) | 24.6 ± 12.18 | −14.12 | 25558.7 ± 15171.82* | 51.77 |
| pVAX1/i.m. (n = 10) | 23.7 ± 5 | −8.09 | 57686.6 ± 20951.58 | −8.86 |
| PBS (n = 10) | 21.6 ± 3.94 | — | 52989.6 ± 19448.42 | — |
|
| ||||
| Trail 2 | ||||
| pVAX1/SjTGR/g.g. (n = 10) | 12.6 ± 7.17* | 38.83 | 33326.5 ± 6875.44* | 44.51 |
| pVAX1/g.g. (n = 10) | 21.6 ± 8.67 | −4.85 | 65934.8 ± 16702.02 | −9.79 |
| PBS (n = 10) | 20.6 ± 4.90 | — | 60055.1 ± 19211.27 | — |
Differences were significant at P < 0.05 (*); data was presented in 95% confidence interval.
aPercent reduction was determined using total worms in immunized group compared to PBS group.
bPercent reduction was calculated using liver egg burden in immunized group compared to PBS group.
cThe number of animals in each group when perfusion.