Table 1.

Comparison of expression levels of TLR signaling pathway and innate immunity genes in SIV-infected REG and RAP CD11b-depleted splenic cells. Expression levels were normalized using the average of 5 housekeeping genes and the ratio between RAP and REG animals' dCT values was calculated issuing fold change. Shown are the genes whose expression is significantly changed between the groups, organized by functional categories of the TLRs and their adapter as well as interacting proteins, the downstream NFκB and JNK/p38 signaling pathways, as well as other related molecules (MAPK8IP3 is present in both the adapter/interacting and the JNK/p38 categories).

TLRs and adapter/interacting	Fold RAP/REG	P value	NFκB & JNK/p38	Fold RAP/REG	P value	Other	Fold RAP/REG	P value
GPC1	9.43	0.0168	ESCIT	10.05	0.0235	CCL2	13.42	0.0193
HRAS	5.72	0.0061	IL10	12.73	0.0497	CD86	8.47	0.0216
LY86	9.96	0.0455	IRAK2	8.07	0.0121	CSF3	12.03	0.0161
MAL	10.28	0.0028	IRAK4	11.15	0.0310	IL6	11.17	0.0239
MAPK8IP3	12.26	0.0031	IRF3	9.74	0.0077	IRF1	9.23	0.0006
MYD88	12.39	0.0450	JUN	11.35	0.0387	IRF7	14.37	0.0412
PGLYRP3	12.08	0.0388	MAP2K3	11.65	0.0229	LTA	10.12	0.0196
SARM1	7.38	0.0335	MAP2K4	8.80	0.0282	PRKRA	12.03	0.0258
TIRAP	7.53	0.0275	MAPK12	10.05	0.0077	TBK1	10.79	0.0476
TLR3	13.90	0.0142	MAPK8IP3	12.26	0.0031
TLR6	4.10	0.0472	NFKB2	8.70	0.0317
TLR9	5.60	0.0489	NFKBIB	12.67	0.0242
TOLLIP	4.70	0.0082	REL	6.45	0.0270
			RELB	9.45	0.0401
			TNF	9.51	0.0034
			TNFRSF1A	8.12	0.0050