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. 2013 Mar 7;9(3):e1003318. doi: 10.1371/journal.pgen.1003318

Figure 1. Phylogeography of the six main Mycobacterium tuberculosis lineages.

Figure 1

A: Phylogenetic tree of the main M. tuberculosis lineages described in our study based on the neighbor-joining phylogeny across 23 M. tuberculosis complex whole-genome sequences (from Ref. [72]). Numbers on branches refer to the corresponding number of single nucleotide polymorphisms inferred. B: Distribution of the main phylogenetic M. tuberculosis lineages among Swiss tuberculosis cases included in the study (n = 518), by geographic origin of the patients. In (A) Mycobacterium canettii was used as the outgroup. SNPs, single nucleotide polymorphisms. In (B) the sizes of the pie charts correspond to the number of patients included in the study: European region (233 patients), Middle-East/North Africa (27), Indian subcontinent (36), Western Pacific (19), Central/South America (24), South-East Asia (48), and Eastern (55), Western (46) and Southern region (30) of sub-Saharan Africa. Lineage 1: Indo-Oceanic lineage; Lineage 2: East-Asian lineage (includes Beijing strains); Lineage 3: Delhi/CAS; Lineage 4: Euro-American lineage; Lineages 5 and 6: West African lineages.