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. 2013 Mar 7;8(3):e58417. doi: 10.1371/journal.pone.0058417

Table 1. Partial list of genes reduced or increased in liver of CD44KO(HFD) mice compared to WT(HFD) mice.

Functional Category GeneBankAccession # Gene Symbol Gene description Fold Change (KO/WT)
Inflammation associated genes
Chemokine
NM_013654 Ccl7 chemokine (C-C motif) ligand 7 -5.23
NM_009987 Cx3cr1 chemokine (C-X3-C) receptor 1 −5.21
NM_013653 Ccl5 chemokine (C-C motif) ligand 5 −4.30
NM_009915 Ccr2 chemokine (C-C motif) receptor 2 −3.50
NM_013652 Ccl4 chemokine (C-C motif) ligand 4 −3.35
NM_008510 Xcl1 chemokine (C motif) ligand 1 −2.68
NM_009142 Cx3cl1 chemokine (C-X3-C motif) ligand 1 −2.42
NM_011888 Ccl19 chemokine (C-C motif) ligand 19 −2.32
NM_008599 Cxcl9 chemokine (C-X-C motif) ligand 9 −2.12
NM_007719 Ccr7 chemokine (C-C motif) receptor 7 −2.10
NM_009917 Ccr5 chemokine (C-C motif) receptor 5 −1.99
NM_007722 Cxcr7 chemokine (C-X-C motif) receptor 7 −1.98
NM_009141 Cxcl5 chemokine (C-X-C motif) ligand 5 −1.95
NM_001025192 Cxadr coxsackie virus and adenovirus receptor −1.68
NM_009910 Cxcr3 chemokine (C-X-C motif) receptor 3 −1.53
NM_018866 Cxcl13 chemokine (C-X-C motif) ligand 13 15.44
Immune response
NM_009851 Cd44 CD44 antigen −18.50
NM_010742 Ly6d lymphocyte antigen 6 complex, locus D −17.13
NM_001081110 Cd8a CD8 antigen, alpha chain −8.94
M17534 CD8b1 CD8 antigen, beta chan 1 −3.39
NM_001042580 Cd63 CD63 antigen −3.19
NM_010555 Il1r2 interleukin receptor 1, type II −1.71
NM_010741 Ly6c1 lymphocyte antigen 6 complex, locus C1 −1.65
NM_019408 Nfkb2 nuclear factor of κ light polypept. enhancer B cells −1.55
Matrix
NM_008607 Mmp13 matrix metallopeptidase 13 −11.90
NM_010809 Mmp3 matrix metallopeptidase 3 −4.54
NM_007742 Col1a1 collagen, type I, alpha 1 −4.37
NM_021334 Itgax integrin alpha X −4.03
NM_008605 Mmp12 matrix metallopeptidase 12 −3.62
NM_007737 Col5a2 collagen, type V, alpha 2 −3.06
NM_145467 Itgbl1 integrin, beta-like 1 −3.05
NM_009930 Col3a1 collagen, type III, alpha 1 −3.03
NM_020008 Clec7a C-type lectin domain family 7, member a −3.27
NM_011580 Thbs1 thrombospondin 1 −3.21
NM_007403 Adam8 a disintegrin and metallopeptidase domain 8 −3.19
Functional Category GeneBankAccession # Gene Symbol Gene description Fold Change (KO/WT)
NM_001038604 Clec5a C-type lectin domain family 5, member a −3.08
NM_033612 Cela1 chymotrypsin-like elastase family, member 1 −2.68
NM_010705 Lgals3 lectin, galactose binding, soluble 3 (Mac-2) −2.51
NM_008495 Lgals1 lectin, galactose binding, soluble 1 −2.35
NM_011693 Vcam1 vascular cell adhesion molecule 1 −2.24
NM_011581 Thbs2 thrombospondin 2 −2.12
AK037794 Itga4 integrin alpha 4 −2.05
NM_010810 Mmp7 matrix metallopeptidase 7 −1.70
NM_008611 Mmp8 matrix metallopeptidase 8 −1.62
AF026509 Itgb3 integrin beta 3 2.94
NM_010766 Marco macrophage receptor with collagenous structure 7.73
Transcription
NM_007498 Atf3 activating transcription factor 3 −2.80
NM_008091 Gata3 GATA binding protein 3 −1.69
NM_009283 Stat1 signal transducer and activator of transcription 1 −1.57
NM_011487 Stat4 signal transducer and activator of transcription 4 −1.57
NM_011756 Zfp36 zinc finger protein 36 1.89
Lipid accumulation associated genes
NM_029001 Elovl7 elongation of long chain fatty acids, member 7 −9.83
NM_007468 Apoa4 apolipoprotein A-IV −5.20
NM_007702 Cidea cell death-inducing DFFA-like effector a −4.42
NM_178373 Cidec cell death-inducing DFFA-like effector c −4.34
NM_027881 Osbpl3 oxysterol binding protein-like 3 −3.7
NM_020564 Sult5a1 sulfotransferase 5A1 −3.62
NM_177448 Mogat2 monoacylglycerol O-acyltransferase 2 −3.54
NM_020568 Plin4 perilipin 4 −2.67
NM_026713 Mogat1 monoacylglycerol O-acyltransferase 1 −2.39
NM_001033336 Abcc4 ATP-binding cassette, sub-family C, member 4 −2.00
NM_015763 Lpin1 lipin 1 −2.00
NM_007988 Fasn fatty acid synthase −1.82
NM_134255 Elovl5 elongation of long chain fatty acids, member 5 −1.70
NM_007643 Cd36 Cd36 antigen −1.55