Figure 1. Identification of ON01210 (Ex-RAD^®) as a radioprotectant from an (E)-Styryl Benzylsulfone chemical library.

(A) Screening protocol used to identify radioprotective compounds from the chemical library. HFL-1 cells were pretreated with varying concentrations of compounds for 24 hours before irradiation (10 Gy), followed by replating into fresh dishes to form colonies. (B) Representative results of cells treated with compounds that show radioprotective activity. (C) ON01210 pretreatment protected HFL-1 cells in a dose responsive manner.