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. 2013 Mar 7;8(3):e58355. doi: 10.1371/journal.pone.0058355

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© 2013 Kang et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Human bone marrow cells were pre-treated with varying concentrations of ON01210.Na (A) or Amifostine (C) and irradiated at 2, 3, and 4 Gy to identify the optimum dose of drug for radioprotection. Varying doses of radiation were used on human bone marrow cells that were pre-treated with 10 uM ON01210.Na (B) or 250 uM Amifostine (D) to calculate the dose reduction factor (DRF). ON01210.Na protected human bone marrow cells with a calculated DRF value of 1.6.