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. 2013 Mar 7;9(3):e1003219. doi: 10.1371/journal.ppat.1003219

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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A) Lesion profiles of Bv109I infected with Bv^109ICWD^PMCA following primary transmission (open circles) and second passage (closed diamonds), compared with Bv109I infected with Bv^109ICWD (triangles). Brain-scoring positions are described in Figure 2. B) Regional distribution, by PET-blot with SAF84 mAb, of PrP^res in Bv109I infected with Bv^109ICWD^PMCA following primary transmission and second passage compared with the control group (Bv^109ICWD). Brain areas are as in Figure 4.