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. 2013 Mar 7;8(3):e58782. doi: 10.1371/journal.pone.0058782

Figure 3. A VAP protein-protein interaction network.

Figure 3

The members of this network are comprised of differentially up-regulated (red) and down-regulated (green) proteins in critically ill patients with VAP relative to those without VAP. Connectivity is based on previously published protein interactions. Note the presence of several densely connected hubs (ITGAM, ITGB2, MPO) that may play important roles in the pathogenesis of VAP (see Discussion). Two members of the proposed limited proteomic signature for diagnosis of VAP (S100A8 and LTF) are also network nodes.