Table 1. Characteristics of the patients, donors, and grafts.
| Total | Systemic follow-up | Symptomatic follow-up | |
| Number(No.) of Patients | 98 | 63 | 35 |
| Median age (Range) | 24(16–48) | 26(16–47) | 23(16–48) |
| Gender of recipients, Male No. (%) | 58(59%) | 35(56%) | 23(66%) |
| Diagnosis, No. (%) | |||
| AML | 42(42%) | 30(48%) | 12(34%) |
| ALL | 37(37%) | 22(35%) | 15(41%) |
| CML | 9 (10%) | 7(10%) | 2(6%) |
| MDS | 7 (6%) | 4(6%) | 3(9%) |
| NHL | 3(2%) | 0(0%) | 3(9%) |
| Donor match (%)* | |||
| Matched | 32(30%) | 20(32%) | 12(34%) |
| Mismatched | 66(67%) | 43(68%) | 23(66%) |
| one locus | 4 | 3 | 1 |
| two loci | 19 | 10 | 9 |
| three loci | 43 | 40 | 13 |
| Source of grafts, no. of patients (%) | |||
| BM+PBSC | 96(98%) | 63 | 33 |
| PB | 2(2%) | 0 | 2 |
| aGvHD | 72 | 37 | 35 |
| Time, median days(range) | 25(15–68) | 24(15–52) | 27(16–68) |
| Grade-1 | 36 | 16 | 20 |
| Grade-2 | 32 | 19 | 13 |
| Grade-3 | 3 | 2 | 1 |
| Grade-4 | 1 | 0 | 1 |
Abbreviations: aGvHD = acute graft-versus-host disease; AML: acute myeloid leukemia; ALL: acute lymphoblastic leukemia; CML: chronic myelogenous leukemia; MDS: myelodysplastic syndromes; NHL: Non Hodgkin lymphoma.
*
Related donors were required to match the recipients for the serological defined HLA-A and-B antigens as well as HLA-DRB1 alleles. HLA-A and -B antigens were typed by DNA methods and HLA-DRB1 alleles were typed with sequence-specific oligonucleotide probes. One locus mismatch meant 5/6 and two loci mismatch meant 4/6. Unrelated donors were additionally required to match HLA-C and HLA-DQB1 alleles.